A precision obesity medicine test for primary care settings

Providers work hard to support patients with obesity, often within a limited amount of time. Determining which treatment will be most effective for each unique patient can be challenging.

The MyPhenomeRx Test helps solve this by detecting whether an individual possesses a particular obesity phenotype (subtype ) - Abnormal Satiation (Hungry Brain^TM) or Abnormal Post-Prandial Satiety (Hungry Gut^TM). Clinical evidence has demonstrated a correlation between obesity phenotypes and response to two mechanistically distinct anti-obesity medications, phentermine-topiramate extended release (ER) and GLP-1s.^1,2

The science behind MyPhenomeRx

The detection of an obesity phenotype is derived from analyzing a proprietary version of a polygenic risk score that uses a combined data set of genes and biometrics. The genetic component uses a broad set of genetic markers called Single Nucleotide Polymorphisms (SNPs). The SNPs analyzed by MyPhenomeRx have key roles in the regulation of appetite through the Glucagon-like Peptide-1 receptor (GLP1R)-Melanocortin 4 Receptor (MC4R) pathway.

The test compares each patient’s biological patterns to our validated phenotype database, supporting a more confident understanding of a patient's biology in the provider's clinical evaluation of obesity.

Learn more about our platform >

Read the clinical validation study published in Cell Metabolism:
' Genetic and physiological insights into satiation variability predict responses to obesity treatment published in cell metabolism '

Read the full study

Process for prescribers

MyPhenomeRx is a prescription only test. Healthcare Providers and Prescribers can order MyPhenomeRx by following the instructions below.

Step 01

Complete account initiation form

Once you complete the account initiation form, you will be redirected to schedule a 30-minute onboarding. Once onboarding has been booked, your account will be setup within 1 business day, and you will receive an email with instructions for logging in.

For prescribers looking to order MyPhenomeRx:

Complete form

Step 02

Attend
onboarding

During the onboarding call, we will walk you through how to place a kit order, how to place lab orders, and how to access/review results within your MyPhenome portal. As well as how to best implement MyPhenomeRx into your practice.

Step 03

Provide MyPhenomeRx to patients

Results will be delivered in the MyPhenome portal. You will be informed via email when a new result is available. You can access your MyPhenome portal anytime here.

Steps for testing

Step 01:
Lab order placed

Step 02:
Sample collected

Step 03:
Results reported

References & Disclaimers

References

Acosta, Andres et al. “Selection of Antiobesity Medications Based on Phenotypes Enhances Weight Loss: A Pragmatic Trial in an Obesity Clinic.” Obesity (Silver Spring, Md.) vol. 29,4 (2021): 662-671. doi:10.1002/oby.23120
Cifuentes, Lizeth et al. “Genetic and physiological insights into satiation variability predict responses to obesity treatment.” Cell metabolism vol. 37,8 (2025): 1655-1666.e5. doi:10.1016/j.cmet.2025.05.008

Disclaimers

Due to New York state restrictions, we cannot process your order if the patient resides in New York state.
This test can only be ordered and fulfilled inside the United States.

MyPhenomeRx