How obesity classification impacts
weight loss strategy

With the current treatment for obesity, data suggests that a patient responses vary widely to weight-loss intervention.  Classifying a disease based on pathophysiologic changes leads to a targeted treatment approach that can maximize outcomes in response to interventions. The four phenotypes we have identified take into consideration homeostatic food intake, hedonic eating, and energy expenditure.

Trial-and-error approach to individualized precision medicine for obesity approach. We are integrating the current knowledge on obesity pathophysiology and existing data accounting for the variability of factors - both internal and external - that impact obesity.

Precision medicine for obesity

Precision medicine is the model of personalized preventive, diagnostic, and therapeutic procedures that strive to improve disease stratification and increase treatment efficacy by considering individual variability.

  • Hungry Brain

    Hungry Brain

    Patients with a hungry brain (abnormal satiation), who require more calories at each meal to reach maximal fullness, might benefit the most from limiting the meal frequency and decreasing their meals' energy density to reduce caloric intake. A low-calorie diet with more dietary fiber in a time restricted fashion is associated with improved appetite sensations, enhanced satiation, and sustained compliance.

     

  • Hungry Gut

    Hungry Gut

    Patients with a hungry gut (abnormal satiety), who have accelerated gastric emptying in relation to lower postprandial concentrations of GLP-1, might benefit from a high protein diet with protein preloads to improve GLP-1. High protein diets resulted in weight loss and improved satiety even with a long-term follow-up. Moreover, protein preloads have been shown to slow gastric emptying in healthy participants and patients with type 2 diabetes within higher postprandial GLP-1 concentrations.

  • Emotional Hunger

    Emotional Hunger

    Patients with emotional hunger phenotype might benefit the most from a behavioral intervention structured for goal-setting, self-monitoring, and stimulus control. Furthermore, mindfulness-based approaches were shown to decrease emotional eating and help by increasing self-awareness.

  • Slow Burn

    Slow Burn

    Low energy expenditure facilitates weight gain by promoting a positive energy balance. The reduced metabolic rate would be the critical issue to tackle among individuals with slow burn. An excellent dose-response relationship was found between resistance training and muscle hypertrophy. Moreover, low-carbohydrate, high-protein diets enhanced changes in muscle strength and size and can increase energy expenditure.

How is MyPhenome test different from other tests on the market?

There are many commercial companies that offer DNA testing which explains factors about genetics, like the traits inherited from parents.  This information is helpful in understanding what has leads to an individuals obesity; however, it doesn't help one understand how to best treat it based on one's unique characteristics. 

Additionally, Microbiome tests are readily available.  These tests focus on the bacteria in the stomach and how carbohydrates are converted to glucose. This information is particularly useful for diabetics and diabetes prevention. 

MyPhenomeTM test is the only test that looks at all multiple layers causing obesity - genetics, metabolism, hormones, and many other factors to tailor treatment and drive meaningful weight loss.   

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