How obesity classification impacts
weight loss strategy

With the current treatment for obesity, data suggests that a patient responses vary widely to weight-loss intervention.  Classifying a disease based on pathophysiologic changes leads to a targeted treatment approach that can maximize outcomes in response to interventions. The four phenotypes we have identified take into consideration homeostatic food intake, hedonic eating, and energy expenditure.

Instead of taking a trial-and-error approach to treating weight loss,  we give you the power to deliver precision medicine to your patients. We integrate the current knowledge on obesity pathophysiology and existing data accounting for the variability of factors - both internal and external - that impact weight.

Precision medicine for obesity

Precision medicine is the model of personalized preventive, diagnostic, and therapeutic procedures that strive to improve disease stratification and increase treatment efficacy by considering individual variability.

  • Hungry Brain

    Hungry Brain

    Patients with a hungry brain (abnormal satiation), who require more calories at each meal to reach maximal fullness, might benefit the most from limiting the meal frequency and decreasing their meals' energy density to reduce caloric intake. A low-calorie diet with more dietary fiber in a time restricted fashion is associated with improved appetite sensations, enhanced satiation, and sustained compliance.


  • Hungry Gut

    Hungry Gut

    Patients with a hungry gut (abnormal satiety), who have accelerated gastric emptying in relation to lower postprandial concentrations of GLP-1, might benefit from a high protein diet with protein preloads to improve GLP-1. High protein diets resulted in weight loss and improved satiety even with a long-term follow-up. Moreover, protein preloads have been shown to slow gastric emptying in healthy participants and patients with type 2 diabetes within higher postprandial GLP-1 concentrations.

  • Emotional Hunger

    Emotional Hunger

    Patients with emotional hunger phenotype might benefit the most from a behavioral intervention structured for goal-setting, self-monitoring, and stimulus control. Furthermore, mindfulness-based approaches were shown to decrease emotional eating and help by increasing self-awareness.

  • Slow Burn

    Slow Burn

    Low energy expenditure facilitates weight gain by promoting a positive energy balance. The reduced metabolic rate would be the critical issue to tackle among individuals with slow burn. An excellent dose-response relationship was found between resistance training and muscle hypertrophy. Moreover, low-carbohydrate, high-protein diets enhanced changes in muscle strength and size and can increase energy expenditure.